Alkynes muaj dav nyob rau hauv cov khoom ntuj, biologically active molecules thiab organic functional khoom.Nyob rau tib lub sijhawm, lawv kuj tseem yog cov nruab nrab tseem ceeb hauv cov organic synthesis thiab tuaj yeem ua rau muaj kev hloov pauv tshuaj lom neeg ntau.Yog li ntawd, kev txhim kho ntawm cov txheej txheem kev tsim kho alkynes yooj yim thiab muaj txiaj ntsig tshwj xeeb yog ceev thiab xav tau.Txawm hais tias Sonogashira cov tshuaj tiv thaiv catalyzed los ntawm cov hlau hloov pauv yog ib txoj hauv kev zoo tshaj plaws thiab yooj yim rau kev sib txuas ntawm aryl lossis alkenyl hloov alkynes, cov tshuaj tiv thaiv sib txuas uas tsis yog siv cov alkyl electrophiles yog vim muaj kev cuam tshuam sab xws li bH tshem tawm.Tseem muaj kev sib tw thiab kev tshawb fawb tsawg dua, feem ntau txwv rau ib puag ncig tsis zoo thiab kim halogenated alkanes.Yog li ntawd, kev tshawb nrhiav thiab kev loj hlob ntawm Sonogashira cov tshuaj tiv thaiv ntawm cov tshiab, pheej yig thiab yooj yim muaj alkylation reagents yuav yog qhov tseem ceeb ntawm kev kuaj sim thiab kev siv hauv kev lag luam.Pab neeg ntse tsim thiab tsim ib qho tshiab, yooj yim muaj thiab ruaj khov amide-hom NN2 pincer ligand, uas thawj zaug pom tau hais tias muaj txiaj ntsig thiab kev xaiv siab ntawm alkylamine derivatives thiab davhlau ya nyob twg alkynes nrog ntau hom nickel catalytic qhov chaw, pheej yig thiab yooj yim rau tau.Cov tshuaj tiv thaiv kev sib txuas tau ua tiav tiav rau lub sijhawm deamination thiab alkynylation hloov kho ntawm cov khoom ntuj tsim thiab cov tshuaj molecules, uas qhia txog kev ua tau zoo ntawm cov tshuaj tiv thaiv thiab kev ua haujlwm pab pawg sib raug zoo, thiab muab qhov tshiab rau kev sib txuas ntawm cov khoom tseem ceeb alkyl-hloov alkynes.Thiab cov txheej txheem siv tau.
Post lub sij hawm: Nov-22-2021