Koj puas ua haujlwm hauv kev tshawb fawb biomedical?Yog tias muaj, ces koj yuav tau hnov sulfo-NHS.Raws li lub luag haujlwm tseem ceeb ntawm qhov sib xyaw no hauv kev tshawb fawb txuas ntxiv tau lees paub, qhov sib xyaw no nkag mus rau ntau lub chaw soj nstuam thoob ntiaj teb.Hauv tsab xov xwm no, peb tham txog dab tsi Sulfo-NHS yog dab tsi thiab vim li cas nws thiaj li muaj txiaj ntsig zoo rau cov uas kawm txog biological sciences.
Ua ntej, Sulfo-NHS yog dab tsi?Lub npe ntev me ntsis, yog li cia peb tawg.Sulfo stands rau sulfonic acid thiab NHS sawv rau N-hydroxysuccinimide.Thaum ob qhov sib xyaw ua ke,Sulfo-NHSyog tsim.Qhov sib xyaw no muaj ntau yam kev siv hauv kev tshawb fawb biomedical, tab sis ib qho ntawm nws cov khoom tseem ceeb yog lub peev xwm los xaiv cov proteins.
Sulfo-NHS ua hauj lwm los ntawm reacting nrog thawj amines (piv txwv li -NH2 pawg) nyob rau sab chains ntawm lysine residues nyob rau hauv cov proteins.Qhov tseem ceeb, Sulfo-NHS compounds "tag" proteins, ua rau lawv yooj yim dua los txheeb xyuas thiab txheeb xyuas ntau yam kev sim.Qhov no tau ua rau ntau qhov chaw ntawm kev tshawb fawb tuaj yeem txav mus tom ntej nrog qhov tseeb ntau dua thiab ntau dua ntawm kev nthuav dav.
Yog li, Sulfo-NHS siv rau dab tsi?Ib qho kev siv ntawm cov tshuaj no yog hauv kev tshawb fawb txog kev tiv thaiv kab mob.Sulfo-NHS tau pom tias muaj txiaj ntsig zoo rau cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv kab mob, qhib txoj hauv kev tshiab rau kev kawm txog kev tiv thaiv kab mob thiab kab mob.Ntxiv thiab,Sulfo-NHStuaj yeem siv rau hauv kev tshawb fawb txog kev sib cuam tshuam ntawm cov protein-protein vim nws tso cai rau cov kws tshawb fawb kom paub sai thiab yooj yim txheeb xyuas thaum ob qho protein sib cuam tshuam.
Lwm thaj chaw uas Sulfo-NHS tau siv dav yog cov proteomics.Proteomics kawm txog cov qauv thiab kev ua haujlwm ntawm tag nrho cov proteins hauv lub cev, thiabSulfo-NHSyog ib qho cuab yeej tseem ceeb hauv kev txheeb xyuas no.Los ntawm tagging cov proteins nrog Sulfo-NHS, cov kws tshawb fawb tuaj yeem ua qhov kev sim kom tau txais cov ntaub ntawv ntxaws ntxiv txog cov kab mob proteome, uas tuaj yeem pab txheeb xyuas cov kab mob biomarkers.
Sulfo-NHS kuj tseem ua lub luag haujlwm hauv kev tsim cov tshuaj tshiab.Thaum cov kws tshawb fawb tab tom sim tsim cov tshuaj tshiab, nws yog ib qho tseem ceeb kom paub tseeb tias nws lub hom phiaj ntawm cov protein thiab tsis muaj lwm yam protein nyob hauv lub cev.Los ntawm kev sivSulfo-NHStxhawm rau xaiv tag cov proteins, cov kws tshawb fawb tuaj yeem txheeb xyuas lub hom phiaj ntawm cov tshuaj muaj peev xwm, uas tuaj yeem pab ua kom cov txheej txheem tsim tshuaj.
Yog li ntawd koj muaj nws!Sulfo-NHS tej zaum yuav tsis yog ib lo lus uas paub zoo sab nraum lub zej zog kev tshawb fawb, tab sis qhov sib xyaw no tau nrawm dhau los ua cov cuab yeej tseem ceeb hauv kev tshawb fawb biomedical.Los ntawm kev tshawb fawb txog kev tiv thaiv kab mob mus rau proteomics rau kev txhim kho tshuaj, Sulfo-NHS tau pab cov kws tshawb fawb ua kom muaj kev vam meej loj hauv cov cheeb tsam no thiab peb zoo siab pom qhov kev tshawb pom dab tsi tuaj tom ntej.
Post lub sij hawm: Jun-12-2023